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Necroptosis, parthanatos, pyroptosis, and ferroptosis are all forms of programmed necrosis, as these types of cell death dismantle the cell in an ordered fashion that is distinctly different from apoptosis or autophagy.Several key cellular mediators and events in these types of PCD have been discovered.In this type of cell death, RIP1 plays a role in the branch point between survival and death .When RIP1 is ubiquitinated, it induces survival signals.The necrosome mediates upstream cell death receptors and downstream executing molecules and events, such as reactive oxygen species (ROS) bursts, plasma membrane permeabilization, and cytosolic ATP reduction .The cellular pathways involving PARP activation and AIF translocation from the mitochondria to the nucleus contribute to parthanatos, a second major programmed necrosis pathway.
This death receptor-specific necrotic death was designated necroptosis .
In addition to necroptosis and parthanatos, other types of programmed necrosis, such as pyroptosis, ferroptosis, oxytosis, pyronecrosis, ETosis, and NETosis have also been identified.
Table 1 outlines various modes of programmed necrosis and their key events and regulatory machinery in comparison with other cell death modes.
Byeong Mo Kim Severance Integrative Research Institute for Cerebral and Cardiovascular Diseases (SIRIC) Yonsei University College of Medicine 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea Tel: 82- 2-2228-0789 E-mail: [email protected] Received Date: August 01, 2017 Accepted Date: September 25, 2017 Published Date: September 27, 2017 Citation: Kim BM (2017) The Implications of Several Forms of Programmed Necrosis for Cancer Therapy. doi:10.4172/1948- 5956.1000484 Copyright: ©2017 Kim BM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Cancer Science & Therapy The dogma that apoptosis and autophagy are the sole forms of Programmed Cell Death (PCD) is no longer accepted, due to the recent discovery of programmed necrosis, a non-apoptotic, non-autophagic form of PCD.